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Ceramide synthase 5 : ウィキペディア英語版 | Ceramide synthase 5
Ceramide synthase 5 (CerS5) is the enzyme encoded in humans by the CERS5 gene. ==Function== CerS5 robustly synthesizes C16-ceramide, which is often considered to be an important pro-apoptotic ceramide. De novo ceramide synthesis is an essential trigger for Bax activation in hypoxia/reoxygenation. Following hypoxia/reoxygenation, CerS5 expression is elevated. Upon knocking down acid sphingomyelinase and CerS5 in NTERA-2 cells, Bax localization to mitochondria was reduced, indicating the importance of CerS5 activity in the apoptosis pathway.
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